Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | MITF | O75030 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.43 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.43 |
| ▸ | ITGAL | P20701 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6249048 | 1.00 | ALDH1A1 (0.49) | ALDH1A1MAPTMITFHTTSMN1; SMN2 | |
| SCHEMBL445868 | 0.94 | ALDH1A1 (0.55) | ALDH1A1MAPTMITFHTTSMN1; SMN2 | |
| SCHEMBL445867 | 0.94 | ALDH1A1 (0.55) | ALDH1A1MAPTMITFHTTSMN1; SMN2 | |
| SCHEMBL446259 | 0.76 | ALDH1A1 (0.53) | ALDH1A1MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL446260 | 0.76 | ALDH1A1 (0.53) | ALDH1A1MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL30279254 | 0.74 | SMN1; SMN2 (0.50) | ALDH1A1HTTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL395055 | 0.74 | SMN1; SMN2 (0.50) | ALDH1A1HTTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6314297 | 0.73 | HPGD (0.62) | ALDH1A1MAPTMITFHTTSMN1; SMN2 | |
| SCHEMBL447370 | 0.70 | HRH3 (0.44) | ALDH1A1MAPTHTTSMN1; SMN2KMT2A | |
| SCHEMBL447371 | 0.70 | HRH3 (0.44) | ALDH1A1MAPTHTTSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537084-A1 | SUBSTITUTED 2-ALKYLAMINE NICOTINIC AMIDE DERIVATIVES AND USE THERE OF | Amgen Inc. (US) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004007458-A1 | SUBSTITUTED 2-ALKYLAMINE NICOTINIC AMIDE DERIVATIVES AND USE THERE OF | AMGEN INC. (US) | 2004-01-22 | — | — | WO | disclosed |
| EP-1358184-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | Amgen Inc. (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002066470-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2002-08-29 | — | — | WO | disclosed |