Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | ACE | P12821 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 2/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5408453 | 1.00 | ATM (0.51) | ATMSIGMAR1AKT1CYP3A4SIRT5 | |
| SCHEMBL5416328 | 1.00 | ATM (0.51) | ATMSIGMAR1AKT1CYP3A4SIRT5 | |
| SCHEMBL5403561 | 0.90 | SIRT5 (0.54) | ATMSIGMAR1AKT1CYP3A4SIRT5 | |
| SCHEMBL5408469 | 0.84 | ATM (0.55) | ATMAKT1CYP3A4ACECTSS | |
| SCHEMBL5914356 | 0.82 | ATM (0.55) | ATMAKT1CYP3A4SIRT5ACE | |
| SCHEMBL5414233 | 0.82 | ATM (0.55) | ATMAKT1CYP3A4SIRT5ACE | |
| SCHEMBL5403794 | 0.82 | AKT1 (0.71) | AKT1ACECTSSCTSLCTSB | |
| SCHEMBL16019025 | 0.80 | SYK (0.48) | ATMSIGMAR1AKT1CYP3A4SIRT5 | |
| SCHEMBL5914377 | 0.80 | ATM (0.53) | ATMAKT1CYP3A4SIRT5ACE | |
| SCHEMBL5412208 | 0.80 | ATM (0.53) | ATMAKT1CYP3A4SIRT5ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005044810-A1 | GLYT2 MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-05-19 | — | — | WO | disclosed |