SCHEMBL6249797

SCHEMBL6249797

CC(=O)Nc1ncc(/C=C/c2ncc([Si](C)(C)C)o2)s1

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
OGA O60502 8/20 0.41
CCNE1 P24864 7/20 0.40
CDK2 P24941 7/20 0.40
CCNE2 O96020 6/20 0.40
CDK4 P11802 5/20 0.39
CCND1 P24385 4/20 0.39
CDK1 P06493 4/20 0.38
CCNB2 O95067 3/20 0.38
CCNB1 P14635 3/20 0.38
CCNB3 Q8WWL7 3/20 0.38
CCND2 P30279 1/20 0.38
CCND3 P30281 1/20 0.38
PIK3CG P48736 1/20 0.37
LMNA P02545 2/20 0.37
MAPT P10636 1/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6249800 1.00 OGA (0.41) OGACCNE1CDK2CCNE2CDK4
SCHEMBL5724716 0.85 CDK2 (0.52) OGACCNE1CDK2CCNE2CDK4
SCHEMBL5725700 0.85 CDK2 (0.52) OGACCNE1CDK2CCNE2CDK4
SCHEMBL5724711 0.85 CDK2 (0.52) OGACCNE1CDK2CCNE2CDK4
SCHEMBL5725996 0.85 CDK2 (0.52) OGACCNE1CDK2CCNE2CDK4
SCHEMBL5725694 0.85 CDK2 (0.52) OGACCNE1CDK2CCNE2CDK4
SCHEMBL14040954 0.84 CDK2 (0.54) OGACCNE1CDK2CCNE2CDK4
SCHEMBL6249237 0.81 KMT2A (0.43) CCNE1CDK2CCNE2CDK4CCND1
SCHEMBL6249236 0.81 KMT2A (0.43) CCNE1CDK2CCNE2CDK4CCND1
SCHEMBL5725414 0.81 CCNE2 (0.55) OGACCNE1CDK2CCNE2CDK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005035541-A1 SILICON COMPOUNDS AND THEIR USE AMEDIS PHARMACEUTICALS LTD. (GB) 2005-04-21 WO claimed
WO-2005035541-A1 SILICON COMPOUNDS AND THEIR USE AMEDIS PHARMACEUTICALS LTD. (GB) 2005-04-21 WO disclosed