Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19493638 | 0.77 | KDM4E (0.37) | KDM4ETP53ALDH1A1HPGDMAPT | |
| SCHEMBL1813535 | 0.68 | MEN1 (0.42) | PDE9AKDM4ETP53ALDH1A1GLA | |
| SCHEMBL11622505 | 0.67 | KDM4E (0.32) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL24046743 | 0.67 | ADORA2A (0.53) | — | |
| SCHEMBL24835534 | 0.66 | ALDH1A1 (0.43) | PDE9AKDM4EALDH1A1GLAGAA | |
| SCHEMBL6244757 | 0.66 | ADORA2A (0.35) | — | |
| SCHEMBL11623684 | 0.65 | KDM4E (0.32) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL2267451 | 0.63 | KDM4E (0.44) | KDM4ETP53ALDH1A1GAAHPGD | |
| SCHEMBL29530274 | 0.63 | KDM4E (0.40) | KDM4ETP53 | |
| SCHEMBL22056718 | 0.62 | PARP1 (0.50) | PDE9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432714-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2005-10-19 | — | — | EP | disclosed |
| EP-1432714-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003029209-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |