Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 17/20 | 0.54 |
| ▸ | RHOA | P61586 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1673685 | 0.87 | GPR119 (0.72) | GPR119 | |
| SCHEMBL27652126 | 0.84 | GPR119 (0.61) | GPR119RHOA | |
| SCHEMBL4790743 | 0.84 | GPR119 (0.61) | GPR119RHOA | |
| SCHEMBL27652169 | 0.81 | GPR119 (0.58) | GPR119 | |
| SCHEMBL5263198 | 0.81 | GPR119 (0.57) | GPR119 | |
| SCHEMBL27631894 | 0.80 | GPR119 (0.63) | GPR119 | |
| SCHEMBL6251383 | 0.78 | GPR119 (0.50) | GPR119RHOANOTUM | |
| SCHEMBL6253510 | 0.77 | GPR119 (0.55) | GPR119 | |
| SCHEMBL6250160 | 0.76 | GPR119 (0.52) | GPR119 | |
| SCHEMBL1673636 | 0.75 | GPR119 (0.72) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599468-A1 | 1,2,3-TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO SUCH AS DIABETES AND HYPERGLYCEMIA | Arena Pharmaceuticals, Inc. (US) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004065380-A1 | 1,2,3-TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PRPPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO SUCH AS DIABETES AND HYPERGLYCEMIA | ARENA PHARMACEUTICALS INC. (US) | 2004-08-05 | — | — | WO | disclosed |