SCHEMBL6251998

SCHEMBL6251998

O=C(NCCc1ccc(CN2CCCC2)cc1)ON1CCC2(CCCCC2)CC1

nearest known ligand 0.49

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 7/20 0.49
CYP2D6 P10635 3/20 0.47
CHRM1 P11229 1/20 0.47
HTR2A P28223 1/20 0.47
ALDH1A1 P00352 4/20 0.42
CYP3A4 P08684 2/20 0.42
MAPK1 P28482 2/20 0.42
USP2 O75604 1/20 0.42
CYP2C19 P33261 1/20 0.42
HSD17B10 Q99714 1/20 0.42
KDM4E B2RXH2 1/20 0.41
TSHR P16473 1/20 0.41
HRH3 Q9Y5N1 3/20 0.41
HTT P42858 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
HDAC1 Q13547 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6227004 0.84 MCHR1 (0.49) MCHR1CYP2D6CHRM1HTR2AALDH1A1
SCHEMBL6224869 0.83 MCHR1 (0.48) MCHR1CYP2D6CHRM1HTR2AALDH1A1
SCHEMBL6704754 0.82 MCHR1 (0.52) MCHR1CYP2D6CHRM1HTR2AALDH1A1
SCHEMBL6246936 0.80 OPRM1 (0.58) HRH3
SCHEMBL6248548 0.79 CHRM4 (0.49) MCHR1CYP2D6CHRM1HTR2AALDH1A1
SCHEMBL6222386 0.79 OPRL1 (0.58) MCHR1CYP2D6CHRM1HTR2AALDH1A1
SCHEMBL6226331 0.78 MCHR1 (0.54) MCHR1CYP2D6CHRM1HTR2AALDH1A1
SCHEMBL6223863 0.78 SMN1; SMN2 (0.60) ALDH1A1HRH3HTTL3MBTL1
SCHEMBL6225272 0.78 MCHR1 (0.56) MCHR1CYP2D6CHRM1HTR2AALDH1A1
SCHEMBL6221442 0.78 MCHR1 (0.55) MCHR1CYP2D6CHRM1HTR2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1534689-A1 NOVEL CARBOXAMIDE COMPOUNDS HAVING AN MCH-ANTAGONISTIC EFFECT, MEDICAMENTS CONTAINING SAID COMPOUNDS, AND METHODS FOR THE PRODUCTION THEREOF BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2005-06-01 EP disclosed
WO-2004024702-A1 NOVEL CARBOXAMIDE COMPOUNDS HAVING AN MCH-ANTAGONISTIC EFFECT, MEDICAMENTS CONTAINING SAID COMPOUNDS, AND METHODS FOR THE PRODUCTION THEREOF BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2004-03-25 WO disclosed