Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Gemifloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.75 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.75 |
| ▸ | DRD1 | P21728 | 1/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.70 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.59 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.59 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TOP2A | P11388 | 2/20 | 0.43 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gemifloxacin SCHEMBL2419850 | 0.86 | DPP4 (1.00) | DPP4CHRM2DRD1KDM4EHSD17B10 | |
| Gemifloxacin SCHEMBL13414391 | 0.86 | DPP4 (1.00) | DPP4CHRM2DRD1KDM4EHSD17B10 | |
| Gemifloxacin SCHEMBL136633 | 0.86 | DPP4 (1.00) | DPP4CHRM2DRD1KDM4EHSD17B10 | |
| Gemifloxacin SCHEMBL136634 | 0.86 | DPP4 (1.00) | DPP4CHRM2DRD1KDM4EHSD17B10 | |
| Gemifloxacin SCHEMBL29662144 | 0.86 | DPP4 (1.00) | DPP4CHRM2DRD1KDM4EHSD17B10 | |
| Gemifloxacin SCHEMBL1444728 | 0.86 | DPP4 (1.00) | DPP4CHRM2DRD1KDM4EHSD17B10 | |
| Gemifloxacin SCHEMBL1950144 | 0.86 | DPP4 (1.00) | DPP4CHRM2DRD1KDM4EHSD17B10 | |
| Gemifloxacin SCHEMBL3252334 | 0.86 | DPP4 (1.00) | DPP4CHRM2DRD1KDM4EHSD17B10 | |
| Gemifloxacin SCHEMBL6930951 | 0.86 | DPP4 (1.00) | DPP4CHRM2DRD1KDM4EHSD17B10 | |
| Gemifloxacin SCHEMBL136635 | 0.86 | DPP4 (1.00) | DPP4CHRM2DRD1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1561465-A2 | Methods of use of fluoroquinolone compounds against bacteria | LG Life Sciences, Ltd. (KR) | 2005-08-10 | — | — | EP | disclosed |