⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridazine SCHEMBL29471424 | 0.94 | — | — | |
| Pyridazine SCHEMBL11423 | 0.94 | TSHR (0.42) | — | |
| Pyridazine SCHEMBL5104 | 0.94 | — | — | |
| Pyridazine SCHEMBL20568253 | 0.89 | — | — | |
| Pyridazine SCHEMBL21222853 | 0.89 | — | — | |
| Pyridazine SCHEMBL21626119 | 0.89 | TSHR (0.39) | — | |
| Benzene SCHEMBL250829 | 0.89 | TSHR (0.50) | — | |
| Pyridazine SCHEMBL21405425 | 0.89 | — | — | |
| Pyridazine SCHEMBL8987981 | 0.89 | — | — | |
| Pyridazine SCHEMBL5361937 | 0.89 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1135231-C | 1,2, 4-triazolo [4,3B ] pyrido [3, 2-D ] pyridazine derivatives and pharmaceutical compositions containing them | ��������-����˹��ҩ����˾ | 2004-01-21 | — | — | CN | claimed |
| CN-1266434-A | 1,2,4-triazolo [4,3-B] pyrido [3,2-D] pyridazine derivatives and pharmaceutical compositions containing them | ALMIRALL PRODESFARMA SA (ES) | 2000-09-13 | — | — | CN | claimed |
| EP-1082309-B1 | PROCESS FOR THE PREPARATION OF A 3(2H)-PYRIDAZINONE- 4-SUBSTITUTED AMINO- 5-CHLORO- DERIVATIVE | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 2005-09-14 | — | — | EP | disclosed |
| CN-1205190-C | Process for preparing 3(2H) -pyridazinone-4-substituted amino-5-chloro-derivatives | EGIS PHARMACEUTICAL WORKS (HU) | 2005-06-08 | — | — | CN | disclosed |
| US-6800758-B1 | REACTING 4-(3-HALOPROPYLAMINO)-5- CHLORO-3(2H)-PYRIDAZINONE WITH N-METHYL- HOMOVERATRYLAMINE IN PRESENCE OF ACID BINDING AGENT AND DIPOLAR APROTIC SOLVENT | EGIS GYOGYSZERGYAR RT. (HU) | 2004-10-05 | — | — | US | disclosed |
| CN-1347407-A | Process for preparation of 3(2H)-pyridazinone-4-substd. amino-5-chloro-deriv. | EGIS PHARMACEUTICAL WORKS (HU) | 2002-05-01 | — | — | CN | disclosed |
| EP-1082309-A1 | PROCESS FOR THE PREPARATION OF A 3(2H)-PYRIDAZINONE- 4-SUBSTITUTED AMINO- 5-CHLORO- DERIVATIVE | EGIS GYOGYSZERGYAR (HU) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999064402-A1 | PROCESS FOR THE PREPARATION OF A 3(2H)-PYRIDAZINONE- 4-SUBSTITUTED AMINO- 5-CHLORO- DERIVATIVE | EGIS Gyógyszergyár Rt. (HU) | 1999-12-16 | — | — | WO | disclosed |