Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5158376 | 0.91 | HTR1A (0.42) | HTR1ASLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL5158387 | 0.91 | HTR1A (0.42) | HTR1ASLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL5160674 | 0.87 | HTR1A (0.47) | HTR1ASLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL5160682 | 0.87 | HTR1A (0.47) | HTR1ASLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL5160666 | 0.84 | HTR1A (0.56) | HTR1ASLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL5160669 | 0.84 | HTR1A (0.56) | HTR1ASLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL5160684 | 0.83 | HTR1A (0.48) | HTR1ASLC6A2SLC6A4SLC6A3MAPT | |
| SCHEMBL5160679 | 0.83 | HTR1A (0.48) | HTR1ASLC6A2SLC6A4SLC6A3MAPT | |
| SCHEMBL5161842 | 0.79 | HTR1A (0.44) | HTR1ASLC6A2SLC6A4SLC6A3MAPT | |
| SCHEMBL5161851 | 0.79 | HTR1A (0.44) | HTR1ASLC6A2SLC6A4SLC6A3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005053701-A1 | COMBINATION OF DOPAMINE AGONISTS AND ARALKYL AND ARALKYLIDENE HETEROCYCLIC LACTAMS AND IMIDES | PFIZER PRODUCTS INC. (US) | 2005-06-16 | — | — | WO | disclosed |