Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 16/20 | 0.60 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624036 | 0.88 | FYN (0.46) | FYNCDK9 | |
| SCHEMBL623828 | 0.88 | FYN (0.46) | FYNCDK9 | |
| SCHEMBL625495 | 0.86 | PIM1 (0.46) | FYN | |
| SCHEMBL625540 | 0.83 | FYN (0.68) | FYN | |
| SCHEMBL624057 | 0.81 | FYN (0.60) | FYNJAK2JAK3PTK2 | |
| SCHEMBL625491 | 0.80 | NAMPT (0.41) | CDK9NAMPT | |
| SCHEMBL625407 | 0.79 | PIK3CA (0.45) | FYNCDK9NAMPT | |
| SCHEMBL624945 | 0.77 | FYN (0.49) | FYN | |
| SCHEMBL624433 | 0.76 | FYN (0.47) | FYNJAK2JAK3PTK2 | |
| SCHEMBL623872 | 0.76 | FYN (0.52) | FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |