Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 7/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MELK | Q14680 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1944318 | 0.91 | MKNK1 (0.45) | MAPTTHRBPOLBTP53SMN1; SMN2 | |
| SCHEMBL1946451 | 0.86 | FYN (0.47) | MAPTTHRBMTORTP53SMN1; SMN2 | |
| SCHEMBL625257 | 0.83 | FYN (0.47) | MAPTTHRBPIM1SMN1; SMN2NPC1 | |
| SCHEMBL1944253 | 0.81 | TP53 (0.53) | MAPTTP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1945276 | 0.80 | MAPT (0.45) | MAPTTHRBPOLBTP53SMN1; SMN2 | |
| SCHEMBL2251631 | 0.80 | MKNK1 (0.59) | MAPTTP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL627315 | 0.80 | MKNK1 (0.37) | LMNAKDM4EHSD17B10MKNK1 | |
| SCHEMBL1946964 | 0.79 | TP53 (0.43) | MAPTTHRBTP53SMN1; SMN2NPC1 | |
| SCHEMBL1945923 | 0.78 | MAPT (0.42) | MAPTTHRBPOLBTP53SMN1; SMN2 | |
| SCHEMBL17004605 | 0.78 | MKNK1 (0.43) | MAPTTP53SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |