Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 10/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5265939 | 0.76 | MAP2K1 (0.40) | MAP2K1HSD17B10TDP1ALDH1A1HTT | |
| SCHEMBL3346582 | 0.76 | MAP2K1 (0.38) | MAP2K1HSD17B10TDP1ALDH1A1HTT | |
| SCHEMBL3344917 | 0.75 | PSEN1 (0.47) | MAP2K1 | |
| SCHEMBL3342525 | 0.74 | BACE1 (0.37) | MAP2K1HSD17B10TDP1ALDH1A1HTT | |
| SCHEMBL3346942 | 0.74 | PSEN1 (0.40) | MAP2K1HSD17B10TDP1ALDH1A1HTT | |
| SCHEMBL6239170 | 0.74 | MAP2K1 (0.43) | MAP2K1HSD17B10TDP1ALDH1A1HTT | |
| SCHEMBL14260844 | 0.74 | MAP2K1 (0.43) | MAP2K1HSD17B10TDP1ALDH1A1HTT | |
| SCHEMBL6239173 | 0.74 | MAP2K1 (0.43) | MAP2K1HSD17B10TDP1ALDH1A1HTT | |
| SCHEMBL4927692 | 0.74 | MAP2K1 (0.43) | MAP2K1HSD17B10TDP1ALDH1A1HTT | |
| SCHEMBL14260861 | 0.74 | MAP2K1 (0.43) | MAP2K1HSD17B10TDP1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554250-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004031154-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-04-15 | — | — | WO | disclosed |