Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6239173 | 1.00 | MAP2K1 (0.43) | MAP2K1HSD17B10TDP1ALDH1A1HTT | |
| SCHEMBL4927692 | 1.00 | MAP2K1 (0.43) | MAP2K1HSD17B10TDP1ALDH1A1HTT | |
| SCHEMBL14260861 | 1.00 | MAP2K1 (0.43) | MAP2K1HSD17B10TDP1ALDH1A1HTT | |
| SCHEMBL14260844 | 0.80 | MAP2K1 (0.43) | MAP2K1HSD17B10TDP1ALDH1A1HTT | |
| SCHEMBL2328287 | 0.77 | CA2 (0.46) | MAP2K1HSD17B10TDP1ALDH1A1HTT | |
| SCHEMBL5644665 | 0.76 | MTNR1A (0.43) | MAP2K1HSD17B10TDP1ALDH1A1HTT | |
| Bromide SCHEMBL6207122 | 0.75 | MTNR1A (0.43) | MAP2K1HSD17B10TDP1ALDH1A1HTT | |
| SCHEMBL6253940 | 0.74 | MAP2K1 (0.47) | MAP2K1HSD17B10TDP1ALDH1A1HTT | |
| SCHEMBL5265939 | 0.69 | MAP2K1 (0.40) | MAP2K1HSD17B10TDP1ALDH1A1HTT | |
| SCHEMBL14395106 | 0.68 | MAP2K1 (0.66) | MAP2K1HSD17B10TDP1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554250-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004031154-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-04-15 | — | — | WO | disclosed |