Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 6/20 | 0.56 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.48 |
| ▸ | PTPRA | P18433 | 1/20 | 0.48 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
| ▸ | HPGDS | O60760 | 4/20 | 0.45 |
| ▸ | LAP3 | P28838 | 3/20 | 0.45 |
| ▸ | ANPEP | P15144 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | IL1RN | P18510 | 1/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.43 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL73700 | 0.88 | ACE (0.51) | PTPN1ACE | |
| SCHEMBL739018 | 0.88 | ACE (0.51) | PTPN1ACE | |
| SCHEMBL21326284 | 0.84 | EPHX1 (0.49) | PTPN1HPGDSEPHX1ACECYP3A4 | |
| SCHEMBL21326281 | 0.84 | EPHX1 (0.49) | PTPN1HPGDSEPHX1ACECYP3A4 | |
| SCHEMBL6414895 | 0.83 | EPHX1 (0.50) | HPGDSEPHX1ACECYP3A4CYP2C19 | |
| SCHEMBL6414892 | 0.83 | EPHX1 (0.50) | HPGDSEPHX1ACECYP3A4CYP2C19 | |
| SCHEMBL18120816 | 0.83 | EPHX1 (0.50) | HPGDSEPHX1ACECYP3A4CYP2C19 | |
| SCHEMBL19719557 | 0.78 | EPHX1 (0.45) | HPGDSEPHX1ACECYP3A4CYP2C19 | |
| SCHEMBL19719555 | 0.78 | EPHX1 (0.45) | HPGDSEPHX1ACECYP3A4CYP2C19 | |
| SCHEMBL8703498 | 0.77 | ACE (0.52) | PTPN1ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005056582-A1 | PTP1B PHOTOPROBES | MERCK FROSST CANADA LTD. (CA) | 2005-06-23 | — | — | WO | disclosed |