Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.59 |
| ▸ | RET | P07949 | 5/20 | 0.55 |
| ▸ | CCNB2 | O95067 | 5/20 | 0.54 |
| ▸ | CDK1 | P06493 | 5/20 | 0.54 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.54 |
| ▸ | CCNB3 | Q8WWL7 | 5/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.54 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 3/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 3/20 | 0.47 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.47 |
| ▸ | SYK | P43405 | 3/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7623938 | 0.86 | CCNB2 (0.63) | MAP3K14RETCCNB2CDK1CCNB1 | |
| SCHEMBL140969 | 0.85 | CCNB2 (0.64) | MAP3K14RETCCNB2CDK1CCNB1 | |
| SCHEMBL12723014 | 0.77 | CDK2 (0.51) | MAP3K14RETCCNB2CDK1CCNB1 | |
| SCHEMBL6259670 | 0.77 | CCNB2 (0.63) | MAP3K14RETCCNB2CDK1CCNB1 | |
| SCHEMBL20030316 | 0.77 | MAP3K14 (0.75) | MAP3K14CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL28691324 | 0.77 | MAP3K14 (0.75) | MAP3K14RETCCNB2CDK1CCNB1 | |
| SCHEMBL12723149 | 0.76 | CCNB2 (0.52) | MAP3K14RETCCNB2CDK1CCNB1 | |
| SCHEMBL12723013 | 0.75 | ABL1 (0.58) | RETCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL12723154 | 0.75 | CDK1 (0.71) | RETCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL30369357 | 0.74 | MAP3K14 (1.00) | MAP3K14CCNB2CDK1CCNB1CCNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002102783-A1 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2002-12-27 | — | — | WO | claimed |
| WO-2005065686-A1 | DIFFERENTIATION MODULATING AGENTS AND USES THEREFOR | ADIPOGEN PHARMACEUTICALS PTY LIMITED (AU) | 2005-07-21 | — | — | WO | disclosed |
| WO-2002102783-A1 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2002-12-27 | — | — | WO | disclosed |