Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 20/20 | 0.64 |
| ▸ | SLC6A4 known ✓ | P31645 | 20/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6254686 | 1.00 | SLC6A2 (0.64) | SLC6A2SLC6A4SLC6A3 | |
| Fumaric Acid SCHEMBL27641056 | 0.92 | SLC6A2 (0.71) | SLC6A2SLC6A4SLC6A3 | |
| Fumaric Acid SCHEMBL4491560 | 0.92 | SLC6A2 (0.71) | SLC6A2SLC6A4SLC6A3 | |
| Fumaric Acid SCHEMBL4491556 | 0.92 | SLC6A2 (0.71) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4481977 | 0.82 | SLC6A4 (0.65) | SLC6A2SLC6A4SLC6A3 | |
| Fumaric Acid SCHEMBL27661549 | 0.81 | SLC6A2 (0.88) | SLC6A2SLC6A4SLC6A3 | |
| Fumaric Acid SCHEMBL4480000 | 0.81 | SLC6A2 (0.88) | SLC6A2SLC6A4SLC6A3 | |
| Fumaric Acid SCHEMBL4480003 | 0.81 | SLC6A2 (0.88) | SLC6A2SLC6A4SLC6A3 | |
| Fumaric Acid SCHEMBL4491210 | 0.79 | SLC6A2 (0.69) | SLC6A2SLC6A4SLC6A3 | |
| Fumaric Acid SCHEMBL4491213 | 0.79 | SLC6A2 (0.69) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005053663-A2 | NOREPINEPHRINE REUPTAKE INHIBITORS USEFUL FOR TREATMENT OF COGNITIVE FAILURE | ELI LILLY AND COMPANY (US) | 2005-06-16 | — | — | WO | disclosed |