Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 20/20 | 0.49 |
| ▸ | EDNRB | P24530 | 10/20 | 0.47 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.46 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | DHPS | P49366 | 1/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.46 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1723226 | 0.90 | EDNRA (0.61) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7428350 | 0.86 | EDNRA (0.53) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL3417935 | 0.84 | EDNRA (0.46) | EDNRAEDNRBNR1I2 | |
| SCHEMBL622948 | 0.84 | MEN1 (0.45) | EDNRAEDNRBDHPS | |
| SCHEMBL7329858 | 0.78 | EDNRA (0.62) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7429594 | 0.77 | EDNRA (0.53) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL9275779 | 0.77 | EDNRA (0.64) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL27405903 | 0.76 | EDNRA (0.40) | EDNRAEDNRB | |
| SCHEMBL7819735 | 0.75 | EDNRA (0.49) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL20450343 | 0.74 | EDNRA (0.60) | EDNRAEDNRBABCC3ABCC4NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603497-A1 | A NOVEL PROCESS FOR PREPARATION OF BOSENTAN | Megafine Pharma (P) Ltd. (IN) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012020421-A1 | A NOVEL PROCESS FOR PREPARATION OF BOSENTAN | MEGAFINE PHARMA (P) LTD. (IN) | 2012-02-16 | — | — | WO | disclosed |