Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 4/20 | 0.41 |
| ▸ | CACNG8 | Q8WXS5 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13303940 | 0.83 | GAA (0.68) | GAAPKMKMT2AMEN1PDE3B | |
| SCHEMBL7028337 | 0.81 | CA12 (0.50) | GAAPKMKMT2AMEN1PDE3B | |
| SCHEMBL7026650 | 0.81 | PARP1 (0.48) | GAAPKMPDE3BPDE3AALDH1A1 | |
| SCHEMBL29133433 | 0.80 | GAA (0.54) | GAAPKMKMT2AMEN1PDE3B | |
| SCHEMBL2056376 | 0.79 | GAA (0.63) | GAAPKMKMT2AMEN1PDE3B | |
| SCHEMBL9619832 | 0.79 | GAA (0.63) | GAAPKMKMT2AMEN1PDE3B | |
| SCHEMBL3818109 | 0.79 | GAA (0.63) | GAAPKMKMT2AMEN1PDE3B | |
| SCHEMBL1763460 | 0.79 | GAA (0.96) | GAAPKMKMT2AMEN1PDE3B | |
| SCHEMBL7597403 | 0.79 | GAA (0.63) | GAAPKMKMT2AMEN1PDE3B | |
| SCHEMBL6766573 | 0.79 | GAA (0.58) | GAAPKMKMT2AMEN1PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003517459-A | — | — | 2003-05-27 | — | — | JP | claimed |
| EP-1173423-A1 | BENZIMIDAZOLONES AND ANALOGUES AND THEIR USE AS PROGESTERONE RECEPTOR LIGANDS | American Home Products Corporation (US) | 2002-01-23 | — | — | EP | claimed |
| WO-2000066564-A1 | BENZIMIDAZOLONES AND ANALOGUES AND THEIR USE AS PROGESTERONE RECEPTOR LIGANDS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-11-09 | — | — | WO | claimed |
| EP-2603079-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | Merck Sharp & Dohme Corp. (US) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |