Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | EEF2K | O00418 | 7/20 | 0.59 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.57 |
| ▸ | IKBKB | O14920 | 1/20 | 0.57 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14954758 | 0.91 | BRAF (0.53) | BRAFMAPTUSP2HTTPTK2B | |
| SCHEMBL1539825 | 0.88 | MEN1 (0.66) | BRAFMAPTUSP2HTTPTK2B | |
| SCHEMBL1539792 | 0.86 | BRAF (0.58) | BRAFMAPTUSP2HTTPTK2B | |
| SCHEMBL14955303 | 0.85 | MEN1 (0.65) | BRAFMAPTUSP2HTTHSD17B10 | |
| SCHEMBL192321 | 0.83 | MAPT (0.59) | BRAFMAPTUSP2HTTHSD17B10 | |
| SCHEMBL18537584 | 0.82 | ALDH1A1 (0.56) | MAPTUSP2HTTHSD17B10ADORA3 | |
| SCHEMBL1775711 | 0.82 | BRAF (0.81) | BRAFMAPTUSP2HTTHSP90AB1 | |
| SCHEMBL3092223 | 0.82 | BRAF (0.64) | BRAFMAPTUSP2HTTHSD17B10 | |
| SCHEMBL3101766 | 0.81 | EEF2K (0.62) | BRAFMAPTUSP2HTTEEF2K | |
| SCHEMBL6252769 | 0.80 | BRAF (0.71) | BRAFMAPTUSP2HTTEEF2K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005058315-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS IKK2 INHIBITORS WITH ANTI-HBV ACTIVITY | RIBAPHARM, INC. (US) | 2005-06-30 | — | — | WO | disclosed |