Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 2/20 | 0.47 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.47 |
| ▸ | PAK4 | O96013 | 14/20 | 0.42 |
| ▸ | IGF1R | P08069 | 5/20 | 0.39 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.39 |
| ▸ | PLK4 | O00444 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.39 |
| ▸ | PRKCG | P05129 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6260019 | 0.86 | PTK2 (0.52) | PTK2PTK2BPAK4IGF1RKDR | |
| SCHEMBL6211636 | 0.86 | PTK2 (0.44) | PTK2PTK2BPAK4IGF1RKDR | |
| SCHEMBL6275030 | 0.80 | PTK2 (0.47) | PTK2PTK2BIGF1RKDRFGFR1 | |
| SCHEMBL6209954 | 0.79 | IGF1R (0.51) | PTK2PTK2BIGF1RKDRFGFR1 | |
| SCHEMBL6209471 | 0.79 | IGF1R (0.47) | PTK2PTK2BIGF1RKDRFGFR1 | |
| SCHEMBL6211871 | 0.79 | PTK2 (0.53) | PTK2PTK2BPAK4IGF1RKDR | |
| SCHEMBL6210226 | 0.79 | PTK2 (0.61) | PTK2PTK2BPAK4IGF1RKDR | |
| SCHEMBL6209186 | 0.77 | PTK2 (0.64) | PTK2PTK2BPAK4IGF1RKDR | |
| SCHEMBL6212411 | 0.77 | PTK2 (0.50) | PTK2PTK2BIGF1RKDRFGFR1 | |
| SCHEMBL6212988 | 0.77 | PTK2 (0.75) | PTK2PTK2BIGF1RKDRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578732-A2 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | Pfizer Products Inc. (US) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004056786-A2 | PYRIMIDINE DERIVATES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PRODUCTS INC. (US) | 2004-07-08 | — | — | WO | disclosed |