Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 8/20 | 0.47 |
| ▸ | PTK2B | Q14289 | 6/20 | 0.47 |
| ▸ | IGF1R | P08069 | 5/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6214288 | 0.85 | PTK2 (0.49) | PTK2PTK2BIGF1RFGFR1KDR | |
| SCHEMBL6210394 | 0.84 | PTK2 (0.60) | PTK2PTK2BIGF1RFGFR1KDR | |
| SCHEMBL6212362 | 0.84 | PTK2 (0.53) | PTK2PTK2BIGF1RFGFR1KDR | |
| SCHEMBL6211607 | 0.82 | PTK2 (0.64) | PTK2PTK2BIGF1RFGFR1KDR | |
| SCHEMBL6211439 | 0.82 | PTK2 (0.53) | PTK2PTK2BIGF1RFGFR1KDR | |
| SCHEMBL6212334 | 0.81 | PTK2 (0.64) | PTK2PTK2BIGF1RFGFR1KDR | |
| SCHEMBL6209954 | 0.81 | IGF1R (0.51) | PTK2PTK2BIGF1RFGFR1KDR | |
| SCHEMBL6210739 | 0.81 | SYK (0.50) | PTK2PTK2BIGF1RFGFR1KDR | |
| SCHEMBL6255244 | 0.80 | PTK2 (0.47) | PTK2PTK2BIGF1RFGFR1KDR | |
| SCHEMBL6213157 | 0.79 | PTK2 (0.61) | PTK2PTK2BIGF1RFGFR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578732-A2 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | Pfizer Products Inc. (US) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004056786-A2 | PYRIMIDINE DERIVATES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PRODUCTS INC. (US) | 2004-07-08 | — | — | WO | disclosed |