Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 5/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MTOR | P42345 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6755046 | 0.95 | SLC6A9 (0.46) | SLC6A9CYP2D6CYP2C19CYP2C9ALDH1A1 | |
| SCHEMBL6753991 | 0.88 | MAPT (0.44) | SLC6A9CYP2D6CYP2C19CYP2C9ALDH1A1 | |
| SCHEMBL6256697 | 0.85 | SLC6A9 (0.42) | SLC6A9CYP2D6CYP2C19CYP2C9ALDH1A1 | |
| SCHEMBL6259766 | 0.85 | SLC6A4 (0.50) | SLC6A9CYP2D6CYP2C19CYP2C9ALDH1A1 | |
| SCHEMBL6749910 | 0.84 | SLC6A9 (0.46) | SLC6A9CYP2D6CYP2C19CYP2C9ALDH1A1 | |
| SCHEMBL6256798 | 0.83 | SLC6A9 (0.41) | SLC6A9CYP2D6CYP2C19CYP2C9ALDH1A1 | |
| SCHEMBL6260295 | 0.83 | SLC7A5 (0.46) | SLC6A9CYP2D6CYP2C19CYP2C9ALDH1A1 | |
| SCHEMBL6254431 | 0.83 | SLC7A5 (0.51) | SLC6A9CYP2D6CYP2C19CYP2C9ALDH1A1 | |
| SCHEMBL6256178 | 0.82 | SLC6A9 (0.46) | SLC6A9CYP2D6CYP2C19CYP2C9ALDH1A1 | |
| SCHEMBL6258830 | 0.82 | SLC6A9 (0.38) | SLC6A9CYP2D6CYP2C19CYP2C9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1284257-B1 | Difluoromethylene aromatic ethers and their use as inhibitors of the glycine type-1 transporter | PFIZER PROD INC (US) | 2005-10-05 | — | — | EP | disclosed |
| US-6710071-B2 | SUCH AS ((3-4-(DIFLUORO(PHENYL)METHYL)PHENOXYL-3-PHENYLPROPYL)METHYLAMINO)ACETIC ACID; FOR THE ENHANCEMENT OF COGNITION AND THE TREATMENT OF SCIZOPHRENIA AND OTHER PSYCHOSES | PFIZER INC | 2004-03-23 | — | — | US | disclosed |
| US-20030045569-A1 | Difluoromethylene aromatic ethers as inhibitors of glycine transport | PFIZER INC. | 2003-03-06 | — | — | US | disclosed |
| EP-1284257-A2 | Difluoromethylene aromatic ethers and their use as inhibitors of the glycine type-1 transporter | Pfizer Products Inc. (US) | 2003-02-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030045569-A1 | Difluoromethylene aromatic ethers as inhibitors of glycine transport | SLC1A2, SLC1A1, SLC1A3 | SLC6A9 9/4885CYP2D6 580/4885CYP2C19 916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.