SCHEMBL6255985

SCHEMBL6255985

C[Si]1(C)C(c2ncc3ccccc3n2)=C(c2ccccc2)C(c2ccccc2)=C1c1ncc2ccccc2n1

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.48
NPC1 O15118 3/20 0.41
RAB9A P51151 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
LMNA P02545 1/20 0.41
MAPT P10636 1/20 0.41
RECQL P46063 1/20 0.41
HTR3A P46098 1/20 0.38
HRH4 Q9H3N8 1/20 0.38
MAOA P21397 4/20 0.36
MAOB P27338 4/20 0.36
HPGD P15428 1/20 0.36
PDE10A Q9Y233 1/20 0.36
NFKB1 P19838 1/20 0.35
NFKB2 Q00653 1/20 0.35
RELA Q04206 1/20 0.35
KMT2A Q03164 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6256314 0.87 CYP1A2 (0.44) CYP1A2NPC1RAB9ASMN1; SMN2LMNA
SCHEMBL6253395 0.85 CYP1A2 (0.43) CYP1A2NPC1RAB9ASMN1; SMN2LMNA
SCHEMBL6253891 0.84 CYP1A2 (0.44) CYP1A2NPC1RAB9ASMN1; SMN2LMNA
SCHEMBL6252744 0.83 CYP1A2 (0.43) CYP1A2NPC1RAB9ASMN1; SMN2LMNA
SCHEMBL6256946 0.80 CYP1A2 (0.42) CYP1A2NPC1RAB9ASMN1; SMN2LMNA
SCHEMBL713218 0.77 CYP1A2 (0.66) CYP1A2NPC1RAB9ASMN1; SMN2LMNA
SCHEMBL31325779 0.77 CYP1A2 (0.66) CYP1A2NPC1RAB9ASMN1; SMN2LMNA
Ammonia Solution, Strong SCHEMBL29085625 0.76 CYP1A2 (0.64) CYP1A2NPC1RAB9ASMN1; SMN2LMNA
Hydrochloric Acid SCHEMBL5787439 0.76 CYP1A2 (0.64) CYP1A2NPC1RAB9ASMN1; SMN2LMNA
SCHEMBL28582795 0.74 CYP1A2 (0.67) CYP1A2NPC1RAB9ASMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1143538-B1 Organic electroluminescent element containing a silacyclopentadiene derivative CHISSO CORP (JP) 2005-09-14 EP disclosed
EP-0754691-B1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORP (JP) 2003-11-19 EP disclosed
EP-1143538-A1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative Chisso Corporation (JP) 2001-10-10 EP disclosed
US-6051319-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 2000-04-18 US disclosed
US-5986121-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1999-11-16 US disclosed
EP-0754691-A2 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1997-01-22 EP disclosed