Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 11/20 | 0.61 |
| ▸ | NPPA | P01160 | 6/20 | 0.61 |
| ▸ | ACE | P12821 | 4/20 | 0.41 |
| ▸ | CPA1 | P15085 | 4/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.41 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.39 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.39 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6256519 | 0.93 | MME (0.64) | MMENPPAACECPA1ACE2 | |
| SCHEMBL6255996 | 0.77 | MME (0.73) | MMENPPAITGB1ITGA4 | |
| SCHEMBL6806381 | 0.73 | MME (0.67) | MMENPPAITGB1ITGA4 | |
| SCHEMBL6807770 | 0.73 | MME (0.60) | MMENPPA | |
| SCHEMBL6807772 | 0.73 | MME (0.60) | MMENPPA | |
| SCHEMBL6808651 | 0.72 | MME (0.65) | MMENPPAITGB1ITGA4 | |
| SCHEMBL6259873 | 0.71 | MME (0.51) | MMENPPAACECPA1ACE2 | |
| SCHEMBL6256523 | 0.71 | MME (0.74) | MMENPPAITGB1ITGA4 | |
| SCHEMBL8334821 | 0.71 | MME (0.64) | MMENPPAITGB1ITGA4 | |
| SCHEMBL6254584 | 0.70 | NPPA (0.54) | MMENPPAACERXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578735-A1 | CYCLOPENTYL GLUTARAMIDES AND THEIR USE AS NEUTRAL ENDOPEPTIDASE INHIBITORS | Pfizer Limited (GB) | 2005-09-28 | — | — | EP | claimed |
| WO-2004056787-A1 | CYCLOPENTYL GLUTARAMIDES AND THEIR USE AS NEUTRAL ENDOPEPTIDASE INHIBITORS | PFIZER LIMITED (GB) | 2004-07-08 | — | — | WO | claimed |