Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 15/20 | 0.42 |
| ▸ | TUBB | P07437 | 15/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 15/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 15/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 15/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 15/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 15/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 15/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 15/20 | 0.42 |
| ▸ | TUBA3E | Q6PEY2 | 15/20 | 0.42 |
| ▸ | TUBA1A | Q71U36 | 15/20 | 0.42 |
| ▸ | TUBA1C | Q9BQE3 | 15/20 | 0.42 |
| ▸ | TUBB6 | Q9BUF5 | 15/20 | 0.42 |
| ▸ | TUBB2B | Q9BVA1 | 15/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 15/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | CDC7 | O00311 | 2/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4174880 | 0.92 | TUBB4A (0.51) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4181012 | 0.89 | CDC7 (0.41) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4163532 | 0.88 | KDR (0.50) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4184448 | 0.87 | KDR (0.40) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4170925 | 0.85 | TUBB4A (0.36) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4182033 | 0.84 | KDR (0.37) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4179188 | 0.82 | KDR (0.46) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4173259 | 0.81 | TUBB4A (0.42) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4173431 | 0.81 | KDR (0.38) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4174845 | 0.80 | KDR (0.45) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005004818-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS ANTICANCER AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-01-20 | — | — | WO | disclosed |