Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 6/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
| ▸ | PPARA | Q07869 | 2/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NNMT | P40261 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6272841 | 0.82 | PPARD (0.43) | PPARDPPARGPPARAMKNK1MKNK2 | |
| SCHEMBL6228805 | 0.80 | MKNK1 (0.50) | PPARDMKNK1MKNK2RCE1HDAC6 | |
| SCHEMBL6539809 | 0.77 | CA12 (0.46) | PPARDMKNK1MKNK2RCE1 | |
| SCHEMBL6539675 | 0.77 | MEN1 (0.51) | PPARDMKNK1MKNK2KDM4EALDH1A1 | |
| SCHEMBL6208237 | 0.76 | MKNK1 (0.50) | PPARDMKNK1MKNK2RCE1GABRA1 | |
| SCHEMBL6256472 | 0.76 | PPARD (0.41) | PPARDPPARGPPARAMKNK1MKNK2 | |
| SCHEMBL6540217 | 0.73 | NR4A2 (0.51) | PPARDMKNK1MKNK2RCE1HDAC6 | |
| SCHEMBL6539080 | 0.69 | IKBKB (0.51) | PPARDKDM4EALDH1A1 | |
| SCHEMBL6235990 | 0.69 | PPARD (0.43) | PPARDMKNK1MKNK2RCE1HDAC6 | |
| SCHEMBL6539905 | 0.69 | RCE1 (0.46) | PPARDMKNK1MKNK2RCE1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583749-A1 | OXAZOLE DERIVATIVES AS INHIBITORS OF CYCLOOXYGENASE | Astellas Pharma Inc. (JP) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004065374-A1 | OXAZOLE DERIVATIVES AS INHIBITORS OF CYCLOOXYGENASE | ASTELLAS PHARMA INC. (JP) | 2004-08-05 | — | — | WO | disclosed |