Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 6/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.44 |
| ▸ | DRD1 | P21728 | 2/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5249004 | 0.86 | PRCP (0.47) | PRCPDRD2HTR1ADRD1CYP2D6 | |
| SCHEMBL27571779 | 0.84 | PRCP (0.62) | PRCPDRD2HTR1ADRD1SLC6A2 | |
| SCHEMBL5283260 | 0.80 | PRCP (0.49) | PRCPDRD2HTR1ADRD1SLC6A2 | |
| SCHEMBL5246787 | 0.78 | KDM4E (0.57) | PRCPDRD2HTR1ACYP2D6 | |
| SCHEMBL6256498 | 0.77 | PRCP (0.49) | PRCPDRD2HTR1ADRD1CYP2D6 | |
| SCHEMBL5298787 | 0.76 | KDM4E (0.59) | PRCPDRD2HTR1ADRD1 | |
| SCHEMBL5244031 | 0.75 | DRD2 (0.46) | PRCPDRD2HTR1ACYP2D6 | |
| SCHEMBL5297369 | 0.75 | PRCP (0.43) | PRCPDRD2HTR1A | |
| SCHEMBL28324837 | 0.73 | DRD2 (0.52) | DRD2HTR1ADRD1SLC6A4CYP2D6 | |
| SCHEMBL26710899 | 0.71 | DRD2 (0.57) | PRCPDRD2HTR1ADRD1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572658-A1 | THE USE OF 4-PHENYL-SUBSTITUTED TETRAHYDROISOQUINOLINES IN THE TREATMENT OF PAIN, MIGRAINE HEADACHES AND URINARY INCONTINENCE | Pharmacia & Upjohn Company LLC (US) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004050628-A1 | THE USE OF 4-PHENYL-SUBSTITUTED TETRAHYDROISOQUINOLINES IN THE TREATMENT OF PAIN, MIGRAINE HEADACHES AND URINARY INCONTINENCE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-06-17 | — | — | WO | disclosed |