Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | PRKDC | P78527 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NAMPT | P43490 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324694 | 0.67 | PIK3R1 (0.55) | PIK3CAPIK3R1KDM4EPOLBGAA | |
| SCHEMBL623944 | 0.67 | SMN1; SMN2 (0.40) | PIK3CAARSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL2453709 | 0.66 | PIK3R1 (0.50) | PIK3CAPIK3R1 | |
| SCHEMBL14656557 | 0.66 | NAMPT (0.52) | PIK3CAPIK3R1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL19553269 | 0.65 | AR (0.42) | ARPRKDCSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL30627541 | 0.63 | PIK3CA (0.59) | PIK3CAPIK3R1KDM4EPOLBLMNA | |
| SCHEMBL184869 | 0.63 | GAA (0.53) | PIK3CAPIK3R1ARSMN1; SMN2KDM4E | |
| SCHEMBL28418430 | 0.63 | AR (0.41) | PIK3CAPIK3R1ARPRKDCSMN1; SMN2 | |
| SCHEMBL13271393 | 0.63 | AR (0.41) | PIK3CAPIK3R1ARPRKDCSMN1; SMN2 | |
| SCHEMBL16002359 | 0.63 | DPP4 (0.41) | PIK3CAPIK3R1ARPRKDCSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |