Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.40 |
| ▸ | RAB9A | P51151 | 7/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | AR | P10275 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624035 | 0.73 | SMN1; SMN2 (0.40) | SMN1; SMN2RAB9ANPC1ARALOX15 | |
| SCHEMBL624034 | 0.70 | LMNA (0.48) | MAPTTP53POLBRXFP1THRB | |
| SCHEMBL29930378 | 0.69 | GPX4 (0.33) | — | |
| SCHEMBL11005420 | 0.67 | PIK3CA (0.45) | PIK3CDPIK3CAPIK3CBMAPTTP53 | |
| SCHEMBL2305450 | 0.67 | SMN1; SMN2 (0.48) | SMN1; SMN2RAB9ANPC1ARALOX15 | |
| SCHEMBL625650 | 0.67 | PIK3CA (0.39) | SMN1; SMN2RAB9ANPC1ARPIK3CA | |
| SCHEMBL1932306 | 0.66 | NPC1 (0.53) | SMN1; SMN2RAB9ANPC1ARPIK3CA | |
| SCHEMBL11005416 | 0.65 | RXFP1 (0.61) | MAPTTP53POLBRXFP1THRB | |
| SCHEMBL2750222 | 0.65 | SMN1; SMN2 (0.49) | SMN1; SMN2RAB9ANPC1ARALOX15 | |
| SCHEMBL2585764 | 0.63 | SMPD3 (0.47) | SMN1; SMN2RAB9ANPC1PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |