Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.53 |
| ▸ | TNF | P01375 | 6/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.49 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.49 |
| ▸ | HCK | P08631 | 2/20 | 0.49 |
| ▸ | CIT | O14578 | 1/20 | 0.49 |
| ▸ | MUSK | O15146 | 1/20 | 0.49 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.49 |
| ▸ | STK10 | O94804 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.49 |
| ▸ | PRKCB | P05771 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6165706 | 0.87 | MAPK14 (0.71) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL6257597 | 0.86 | MAPK14 (0.52) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL7855430 | 0.86 | MAPK14 (0.54) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL6573925 | 0.85 | MAPK14 (0.51) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL5618844 | 0.83 | MAPK14 (0.65) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL6578339 | 0.83 | MAPK14 (0.56) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL6575226 | 0.81 | MAPK14 (0.54) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL6576675 | 0.81 | MAPK14 (0.56) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL6263852 | 0.81 | ABL1 (0.51) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL6676531 | 0.80 | MAPK14 (0.58) | MAPK14TNFMAPK12MAPK13MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1408950-A2 | METHODS OF TREATING CYTOKINE MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2004-04-21 | — | — | EP | claimed |
| WO-2003005999-A2 | METHODS OF TREATING CYTOKINE MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2003-01-23 | — | — | WO | claimed |
| EP-1147104-A1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTIINFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2001-10-24 | — | — | EP | claimed |
| WO-2000043384-A1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTIINFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2000-07-27 | — | — | WO | claimed |
| EP-1545514-A1 | ANTICOAGULANT AND FIBRINOLYTIC THERAPY USING P38 MAP KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004016267-A1 | ANTICOAGULANT AND FIBRINOLYTIC THERAPY USING P38 MAP KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-02-26 | — | — | WO | disclosed |
| EP-1147104-A1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTIINFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000043384-A1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTIINFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2000-07-27 | — | — | WO | disclosed |