Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.58 |
| ▸ | ABL1 | P00519 | 3/20 | 0.56 |
| ▸ | RAF1 | P04049 | 3/20 | 0.56 |
| ▸ | LYN | P07948 | 3/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.56 |
| ▸ | SRC | P12931 | 2/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | BRAF | P15056 | 2/20 | 0.51 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.51 |
| ▸ | EPHA3 | P29320 | 2/20 | 0.51 |
| ▸ | AKT1 | P31749 | 1/20 | 0.51 |
| ▸ | TNF | P01375 | 6/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.44 |
| ▸ | HCK | P08631 | 2/20 | 0.44 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.44 |
| ▸ | CIT | O14578 | 1/20 | 0.44 |
| ▸ | MUSK | O15146 | 1/20 | 0.44 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6261564 | 0.87 | MAPK14 (0.52) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL6676634 | 0.85 | MAPK14 (0.49) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL6263852 | 0.85 | ABL1 (0.51) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL6573925 | 0.85 | MAPK14 (0.51) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL6165706 | 0.82 | MAPK14 (0.71) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4091692 | 0.82 | MAPK14 (0.84) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL6257013 | 0.80 | MAPK14 (0.53) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4091873 | 0.80 | MAPK14 (0.81) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4087013 | 0.79 | ABL1 (0.85) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL7855430 | 0.79 | MAPK14 (0.54) | MAPK14ABL1RAF1LYNMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427412-A1 | METHODS OF TREATING CYTOKINE MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2004-06-16 | — | — | EP | disclosed |
| WO-2003022273-A1 | METHODS OF TREATING CYTOKINE MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2003-03-20 | — | — | WO | disclosed |