SCHEMBL6257808

SCHEMBL6257808

CC[Si]1(C)C(c2c(F)c(F)c(F)c(F)c2F)=C(c2ccccc2)C(c2ccccc2)=C1c1c(F)c(F)c(F)c(F)c1F

nearest known ligand 0.31

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
NR1H2 P55055 1/20 0.31
NR1H3 Q13133 1/20 0.31
MAPT P10636 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6258687 0.89 ELANE (0.37)
SCHEMBL6257884 0.87
SCHEMBL6254629 0.86 NR1H2 (0.31) NR1H2NR1H3
SCHEMBL6256103 0.83 MAPT (0.35) NR1H2NR1H3MAPTSMN1; SMN2L3MBTL1
SCHEMBL6255846 0.81
SCHEMBL6259236 0.81 PDE4B (0.32) MAPT
SCHEMBL6253450 0.81 PTGS1 (0.39) MAPTSMN1; SMN2L3MBTL1
SCHEMBL6259847 0.79 NPC1 (0.35) MAPTSMN1; SMN2L3MBTL1
SCHEMBL6257694 0.78 TAAR1 (0.38) MAPTSMN1; SMN2L3MBTL1
SCHEMBL6254041 0.77 TOP1 (0.33) MAPTSMN1; SMN2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1143538-B1 Organic electroluminescent element containing a silacyclopentadiene derivative CHISSO CORP (JP) 2005-09-14 EP disclosed
EP-0754691-B1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORP (JP) 2003-11-19 EP disclosed
EP-1143538-A1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative Chisso Corporation (JP) 2001-10-10 EP disclosed
US-6051319-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 2000-04-18 US disclosed
EP-0754691-A2 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1997-01-22 EP disclosed