SCHEMBL6259236

SCHEMBL6259236

C[Si]1(C)C(c2c(F)c(F)c(F)c(F)c2F)=C(c2ccccc2)C(c2ccccc2)=C1c1c(F)c(F)c(F)c(F)c1F

nearest known ligand 0.32

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PDE4B Q07343 1/20 0.32
ALDH1A1 P00352 1/20 0.32
PTGS1 P23219 1/20 0.30
LMNA P02545 1/20 0.30
MAPT P10636 1/20 0.30
HTT P42858 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6259225 0.87 ELANE (0.40)
SCHEMBL6257884 0.82
SCHEMBL6254629 0.81 NR1H2 (0.31)
SCHEMBL6257808 0.81 NR1H2 (0.31) MAPT
SCHEMBL6253668 0.80
SCHEMBL81272 0.80 ALDH1A1 (0.40) PDE4BALDH1A1LMNAMAPTHTT
SCHEMBL6256900 0.80 ACHE (0.39)
SCHEMBL6254170 0.79 AKR1C2 (0.32)
SCHEMBL6257478 0.78 PTGS1 (0.43) PTGS1MAPT
SCHEMBL6253057 0.77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1143538-B1 Organic electroluminescent element containing a silacyclopentadiene derivative CHISSO CORP (JP) 2005-09-14 EP disclosed
EP-0754691-B1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORP (JP) 2003-11-19 EP disclosed
EP-1143538-A1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative Chisso Corporation (JP) 2001-10-10 EP disclosed
US-6051319-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 2000-04-18 US disclosed
EP-0754691-A2 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1997-01-22 EP disclosed