Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 2/20 | 0.56 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3287154 | 0.94 | MAPT (0.61) | CRHBPCRHR2MAPTCYP1A2CYP2D6 | |
| SCHEMBL13779832 | 0.88 | HRH4 (0.57) | CRHBPCRHR2MAPTCYP1A2KMT2A | |
| SCHEMBL14024999 | 0.85 | MAPT (0.56) | CRHBPCRHR2MAPTCYP1A2CYP2D6 | |
| SCHEMBL3634900 | 0.84 | HRH4 (0.61) | CRHBPCRHR2MAPTCYP1A2CYP2D6 | |
| SCHEMBL908493 | 0.82 | MAPT (0.71) | CRHBPCRHR2MAPTCYP1A2CYP2D6 | |
| SCHEMBL3637243 | 0.82 | CYP1A2 (0.49) | CRHBPCRHR2MAPTCYP1A2CYP2D6 | |
| SCHEMBL23299953 | 0.80 | KMT2A (0.56) | CRHBPCRHR2MAPTCYP1A2CYP2D6 | |
| SCHEMBL15938813 | 0.80 | CYP2C19 (0.56) | CRHBPCRHR2MAPTCYP1A2CYP2D6 | |
| SCHEMBL9640988 | 0.79 | KMT2A (0.69) | KMT2AMEN1HTTHRH4PIK3CA | |
| SCHEMBL9640164 | 0.79 | KMT2A (0.69) | KMT2AMEN1HTTHRH4PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546129-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS ANTITUMOR AGENT | Pharmacia Italia S.p.A. (IT) | 2005-06-29 | — | — | EP | claimed |
| WO-2004024711-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS ANTITUMOR AGENT | PHARMACIA ITALIA S.P.A. (IT) | 2004-03-25 | — | — | WO | claimed |
| EP-1546129-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS ANTITUMOR AGENT | Pharmacia Italia S.p.A. (IT) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004024711-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS ANTITUMOR AGENT | PHARMACIA ITALIA S.P.A. (IT) | 2004-03-25 | — | — | WO | disclosed |