Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | CASP1 | P29466 | 4/20 | 0.65 |
| ▸ | CASP5 | P51878 | 4/20 | 0.65 |
| ▸ | CASP4 | P49662 | 3/20 | 0.65 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.55 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9640164 | 1.00 | KMT2A (0.69) | KMT2ACASP1CASP5CASP4HRH4 | |
| SCHEMBL9639621 | 0.98 | KMT2A (0.67) | KMT2ACASP1CASP5CASP4HRH4 | |
| SCHEMBL9003193 | 0.94 | KMT2A (0.76) | KMT2ACASP1CASP5CASP4HRH4 | |
| SCHEMBL29754406 | 0.88 | CASP1 (0.80) | KMT2ACASP1CASP5CASP4HRH4 | |
| SCHEMBL8962166 | 0.86 | CASP1 (0.77) | CASP1CASP5CASP4HRH4SMN1; SMN2 | |
| SCHEMBL9069830 | 0.85 | CASP1 (0.71) | KMT2ACASP1CASP5CASP4HRH4 | |
| SCHEMBL9722906 | 0.85 | KMT2A (0.65) | KMT2ACASP1CASP5CASP4HRH4 | |
| SCHEMBL19479135 | 0.84 | CYP1A2 (0.62) | KMT2ACASP1CASP5CASP4HRH4 | |
| SCHEMBL1123988 | 0.82 | KMT2A (0.61) | KMT2AHRH4NPSR1PIK3CAMAP3K12 | |
| SCHEMBL1123993 | 0.82 | KMT2A (0.61) | KMT2AHRH4NPSR1PIK3CAMAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0496746-A1 | PHARMACEUTICALLY ACTIVE AMINO-SUBSTITUTED HETEROARYL AMINES | THE UPJOHN COMPANY (US) | 1992-08-05 | — | — | EP | claimed |