Styrene

Styrene

SCHEMBL6258482

C=Cc1ccccc1.c1ccccc1.c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 1.00
TSHR P16473 1/20 1.00
TDP1 Q9NUW8 2/20 0.48
TP53 P04637 1/20 0.48
MAOB P27338 2/20 0.47
CYP2A6 P11509 1/20 0.47
HDAC8 Q9BY41 3/20 0.46
LMNA P02545 3/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
NFE2L2 Q16236 1/20 0.39
CYP19A1 P11511 1/20 0.39
MAOA P21397 1/20 0.39
TRPA1 O75762 1/20 0.39
ALOX5 P09917 1/20 0.39
MAPK1 P28482 1/20 0.39
AKT1 P31749 1/20 0.38
HDAC3 O15379 1/20 0.38
TNKS O95271 1/20 0.38
HDAC4 P56524 1/20 0.38
HDAC1 Q13547 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Styrene SCHEMBL8465847 1.00 ALDH1A1 (1.00) ALDH1A1TSHRTDP1TP53MAOB
Styrene SCHEMBL11144289 1.00 ALDH1A1 (1.00) ALDH1A1TSHRTDP1TP53MAOB
Styrene SCHEMBL8100955 1.00 ALDH1A1 (1.00) ALDH1A1TSHRTDP1TP53MAOB
Styrene SCHEMBL140 1.00
Styrene SCHEMBL1226310 1.00 ALDH1A1 (1.00) ALDH1A1TSHRTDP1TP53MAOB
Styrene SCHEMBL9776790 1.00 ALDH1A1 (1.00) ALDH1A1TSHRTDP1TP53MAOB
Styrene SCHEMBL10892600 1.00 ALDH1A1 (1.00) ALDH1A1TSHRTDP1TP53MAOB
Styrene SCHEMBL4986035 1.00 ALDH1A1 (1.00) ALDH1A1TSHRTDP1TP53MAOB
Styrene SCHEMBL369036 1.00 ALDH1A1 (1.00) ALDH1A1TSHRTDP1TP53MAOB
Styrene SCHEMBL14158601 1.00 ALDH1A1 (1.00) ALDH1A1TSHRTDP1TP53MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786006-B1 CEPHALOSPORIN C AMIDOHYDROLASE, PRODUCTION AND USE GLAXO GROUP LTD (GB) 2005-09-28 EP disclosed
US-6297032-B1 EXPRESSING ENZYME ASSOCIATED WITH THE DEGRADATION OF PREFERENTIAL ANTIBIOTIC; TRANSFORM AND CULTURE CELLS, RECOVER PREFERENTIAL PROTEIN GLAXO GROUP LIMITED (GB) 2001-10-02 US disclosed
US-5919648-A ONE STEP CONVERSION OF CEPHALOSPORIN C OR DERIVATIVE INTO 7-AMINOCEPHALOSPORANIC ACID OR DERIVATIVE USING AMINOHYDROLASE FROM PSUEDOMONAS VESICULARIS B965; FOR CEPHALOTHIN, CEPHALORIDINE, AND CEFUROXIME SYNTHESIS GLAXO GROUP LIMITED (GB) 1999-07-06 US disclosed
EP-0786006-A2 CEPHALOSPORIN C AMIDOHYDROLASE, PRODUCTION AND USE GLAXO GROUP LIMITED (GB) 1997-07-30 EP disclosed
WO-1996016174-A2 CEPHALOSPORIN C AMIDOHYDROLASE, PRODUCTION AND USE GLAXO GROUP LIMITED (GB) 1996-05-30 WO disclosed
US-4165441-A CATALYTIC OXIDATIVE DEHYDROGENATION OF 4-VINYLCYCLOHEXENE WITH OXIDES OF TIN AND ANTIMONY MITSUBISHI CHEMICAL INDUSTRIES, LTD. (JP) 1979-08-21 US disclosed