Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | MTOR | P42345 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6257279 | 0.90 | SLC6A9 (0.50) | MEN1KMT2ALMNANPC1CYP2D6 | |
| SCHEMBL6254431 | 0.84 | SLC7A5 (0.51) | MEN1KMT2ALMNANPC1CYP2D6 | |
| SCHEMBL6259766 | 0.82 | SLC6A4 (0.50) | MEN1KMT2ALMNANPC1CYP2D6 | |
| SCHEMBL6749875 | 0.82 | SLC6A9 (0.50) | MEN1KMT2ALMNANPC1CYP2D6 | |
| SCHEMBL6259263 | 0.81 | SLC6A9 (0.49) | MEN1KMT2ALMNANPC1CYP2D6 | |
| SCHEMBL6257821 | 0.80 | SLC6A9 (0.45) | MEN1KMT2ALMNANPC1CYP2D6 | |
| SCHEMBL6258432 | 0.80 | SLC6A4 (0.50) | MEN1KMT2ALMNANPC1CYP2D6 | |
| SCHEMBL6258546 | 0.80 | SLC6A9 (0.66) | CYP2D6CYP2C19SLC6A4CYP2C9HRH3 | |
| SCHEMBL6755047 | 0.78 | SLC6A4 (0.50) | MEN1KMT2ALMNANPC1CYP2D6 | |
| SCHEMBL6260298 | 0.78 | SLC7A5 (0.47) | MEN1KMT2ALMNANPC1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1284257-B1 | Difluoromethylene aromatic ethers and their use as inhibitors of the glycine type-1 transporter | PFIZER PROD INC (US) | 2005-10-05 | — | — | EP | disclosed |
| EP-1284257-A2 | Difluoromethylene aromatic ethers and their use as inhibitors of the glycine type-1 transporter | Pfizer Products Inc. (US) | 2003-02-19 | — | — | EP | disclosed |