Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | YAP1 | P46937 | 1/20 | 0.36 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10693175 | 0.95 | S1PR3 (0.35) | S1PR3YAP1TEAD4SNCAALDH1A1 | |
| SCHEMBL10694166 | 0.94 | S1PR3 (0.37) | S1PR3YAP1TEAD4SNCAALDH1A1 | |
| SCHEMBL7709597 | 0.94 | S1PR3 (0.37) | S1PR3YAP1TEAD4SNCAALDH1A1 | |
| SCHEMBL10688796 | 0.94 | S1PR3 (0.37) | S1PR3YAP1TEAD4SNCAALDH1A1 | |
| SCHEMBL10694624 | 0.94 | S1PR3 (0.37) | S1PR3YAP1TEAD4SNCAALDH1A1 | |
| SCHEMBL10966413 | 0.94 | S1PR3 (0.37) | S1PR3YAP1TEAD4SNCAALDH1A1 | |
| SCHEMBL9148842 | 0.94 | S1PR3 (0.37) | S1PR3YAP1TEAD4SNCAALDH1A1 | |
| SCHEMBL10693387 | 0.94 | S1PR3 (0.37) | S1PR3YAP1TEAD4SNCAALDH1A1 | |
| SCHEMBL755115 | 0.90 | YAP1 (0.38) | YAP1TEAD4SNCAALDH1A1HSD17B10 | |
| SCHEMBL10598218 | 0.90 | SNCA (0.39) | S1PR3SNCAALDH1A1HSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005065074-A2 | PROTECTION OF TISSUES AND CELLS FROM CYTOTOXIC EFFECTS OF IONIZING RADIATION BY ABL INHIBITORS | TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2005-07-21 | — | — | WO | disclosed |
| US-6638929-B2 | Compounds containing nicotinonitrile rings; anticarcinogenic and -tumor agents; polycystic kidney disease and colonic polyps; antiproliferative agents; angiogenesis inhibitors; restenosis; atherosclerosis; angiofibromas; hemangiomas; | WYETH | 2003-10-28 | — | — | US | disclosed |
| US-20010051620-A1 | Tricyclic protein kinase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-12-13 | — | — | US | disclosed |
| EP-0667347-B1 | Beta-carboline thromboxane synthase inhibitors | LILLY CO ELI (US) | 2001-11-21 | — | — | EP | disclosed |
| US-5604236-A | PYRIDO(3,4-B)INDOLES AS ENZYME INHIBITOR, POTENT THAN ASPIRIN | ELI LILLY AND COMPANY (US) | 1997-02-18 | — | — | US | disclosed |
| EP-0667347-A1 | Beta-carboline thromboxane synthase inhibitors | ELI LILLY AND COMPANY (US) | 1995-08-16 | — | — | EP | disclosed |
| US-4792551-A | 9-anthryloxyaminoalkanes and related compounds as anti-inflammatory and analgetic agents | SYNTEX (U.S.A.) INC. (US) | 1988-12-20 | — | — | US | disclosed |
| US-4696935-A | 3,6-BIS(2-(PIPERIDINO)ETHOXY)ACRIDINE | AMERICAN CYANAMID COMPANY (US) | 1987-09-29 | — | — | US | disclosed |
| EP-0031407-B1 | SUBSTITUTED 3,6 BIS-(AMINOALKOXY)ACRIDINES, AND A PROCESS FOR THEIR PREPARATION | AMERICAN CYANAMID COMPANY (US) | 1987-04-22 | — | — | EP | disclosed |
| US-4593029-A | Enzyme inhibitor | SYNTEX (U.S.A.) INC. (US) | 1986-06-03 | — | — | US | disclosed |
| EP-0132351-A2 | 9-Anthryloxyaminoalkanes and related compounds, processes for their preparation and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1985-01-30 | — | — | EP | disclosed |
| US-4314061-A | Certain 3,6-bis-(heteroaminoalkoxy) acridines | AMERICAN CYANAMID COMPANY | 1982-02-02 | — | — | US | disclosed |
| EP-0031407-A1 | Substituted 3,6 bis-(aminoalkoxy)acridines, and a process for their preparation | AMERICAN CYANAMID COMPANY (US) | 1981-07-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010051620-A1 | Tricyclic protein kinase inhibitors | CDK1, CHEK1, ABL1 | S1PR3 3006/4885YAP1 769/4885TEAD4 841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.