Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 8/20 | 0.61 |
| ▸ | FYN | P06241 | 2/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.43 |
| ▸ | MAST3 | O60307 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6264936 | 0.89 | MAPK8 (0.58) | SYKMAPK8BTKAURKAADORA3 | |
| SCHEMBL6262086 | 0.88 | SYK (0.60) | SYKMAPK8BTKMAST3 | |
| SCHEMBL6260383 | 0.88 | SYK (0.59) | SYKMAPK8BTKAURKAADORA3 | |
| SCHEMBL6264254 | 0.86 | FYN (0.48) | SYKFYNMAPK8BTKAURKA | |
| SCHEMBL6265215 | 0.84 | BTK (0.58) | SYKBTKAURKAADORA3TMIGD3 | |
| SCHEMBL6265223 | 0.83 | PIK3CA (0.53) | SYKMAPK8BTKAURKA | |
| SCHEMBL6263073 | 0.83 | RXFP1 (0.55) | SYKBTKAURKA | |
| SCHEMBL6260272 | 0.83 | MAPK8 (0.49) | SYKMAPK8MAST3 | |
| SCHEMBL6270503 | 0.82 | AURKA (0.57) | SYKMAPK8BTKAURKA | |
| SCHEMBL6265891 | 0.82 | PIK3CA (0.47) | SYKMAPK8AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005085252-A1 | IMIDAZO ‘1,2-A’ PYRAZINE COMPOUNDS WHICH INTERACT WITH PROTEIN KINASES | BIOFOCUS DISCOVERY LIMITED (GB) | 2005-09-15 | — | — | WO | claimed |