Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.58 |
| ▸ | AURKA | O14965 | 3/20 | 0.57 |
| ▸ | SYK | P43405 | 12/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.52 |
| ▸ | ATR | Q13535 | 1/20 | 0.52 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6264936 | 0.89 | MAPK8 (0.58) | BTKAURKASYKADORA3TMIGD3 | |
| SCHEMBL6262086 | 0.88 | SYK (0.60) | BTKSYK | |
| SCHEMBL6260383 | 0.86 | SYK (0.59) | BTKAURKASYKADORA3TMIGD3 | |
| SCHEMBL24864104 | 0.85 | EPHB4 (0.58) | BTKAURKASYKEPHB4 | |
| SCHEMBL6263073 | 0.85 | RXFP1 (0.55) | BTKAURKASYKEPHB4ALDH1A1 | |
| SCHEMBL6260272 | 0.85 | MAPK8 (0.49) | SYKEPHB4 | |
| SCHEMBL24864111 | 0.85 | BTK (0.55) | BTKAURKASYKEPHB4 | |
| SCHEMBL6260435 | 0.84 | SYK (0.61) | BTKAURKASYKADORA3TMIGD3 | |
| SCHEMBL6261492 | 0.82 | MAPK8 (0.50) | ADORA3TMIGD3 | |
| SCHEMBL6265223 | 0.82 | PIK3CA (0.53) | BTKAURKASYKEPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005085252-A1 | IMIDAZO ‘1,2-A’ PYRAZINE COMPOUNDS WHICH INTERACT WITH PROTEIN KINASES | BIOFOCUS DISCOVERY LIMITED (GB) | 2005-09-15 | — | — | WO | claimed |