Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.58 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.50 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.50 |
| ▸ | PI4KA | P42356 | 1/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.50 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.50 |
| ▸ | SCN4A | P35499 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14277965 | 0.84 | KEAP1 (0.53) | KEAP1PIK3CDPIP5K1CPIK3CAPIK3CB | |
| SCHEMBL18985959 | 0.84 | KEAP1 (0.63) | KEAP1PIK3CDPIP5K1CPIK3CAPIK3CB | |
| SCHEMBL6248507 | 0.81 | KEAP1 (0.59) | KEAP1PIK3CDPIP5K1CPIK3CAPIK3CB | |
| SCHEMBL28481731 | 0.79 | SCN4A (0.49) | KEAP1PIK3CDPIP5K1CPIK3CAPIK3CB | |
| SCHEMBL12491752 | 0.79 | KEAP1 (0.58) | KEAP1PIK3CDPIP5K1CPIK3CAPIK3CB | |
| SCHEMBL25258347 | 0.79 | KEAP1 (0.58) | KEAP1PIK3CDPIP5K1CPIK3CAPIK3CB | |
| SCHEMBL14259444 | 0.79 | KEAP1 (0.58) | KEAP1PIK3CDPIP5K1CPIK3CAPIK3CB | |
| SCHEMBL17091191 | 0.79 | KEAP1 (0.49) | KEAP1PIK3CDPIP5K1CPIK3CAPIK3CB | |
| SCHEMBL29598874 | 0.77 | KCNH2 (0.53) | KEAP1PIK3CDPIP5K1CPIK3CAPIK3CB | |
| SCHEMBL3346678 | 0.77 | KEAP1 (0.59) | KEAP1PIK3CDPIP5K1CPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432714-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2005-10-19 | — | — | EP | disclosed |
| EP-1432714-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003029209-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |