Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14061760 | 1.00 | MEN1 (0.40) | MEN1KMT2ATDP1CHRNB4CHRNA3 | |
| Ammonium Lupinoate SCHEMBL4037708 | 0.89 | TDP1 (0.47) | MEN1KMT2ATDP1 | |
| Ammonium Lupinoate SCHEMBL27185103 | 0.88 | TDP1 (0.46) | MEN1KMT2ATDP1ALDH1A1 | |
| Ammonium Lupinoate SCHEMBL29108995 | 0.88 | TDP1 (0.46) | MEN1KMT2ATDP1ALDH1A1 | |
| Ammonium Lupinoate SCHEMBL29108993 | 0.88 | TDP1 (0.46) | MEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL10340118 | 0.87 | TDP1 (0.44) | MEN1KMT2ATDP1 | |
| SCHEMBL10340120 | 0.87 | TDP1 (0.44) | MEN1KMT2ATDP1 | |
| SCHEMBL10340119 | 0.87 | TDP1 (0.44) | MEN1KMT2ATDP1 | |
| SCHEMBL16757394 | 0.81 | CHRNB4 (0.41) | MEN1KMT2ATDP1CHRNB4CHRNA3 | |
| SCHEMBL27875347 | 0.81 | TDP1 (0.38) | MEN1KMT2ATDP1CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106795171-A | Antibacterial basic biaromatic derivatives with aminoalkoxy substitution | 埃科特莱茵药品有限公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-103965200-A | Substituted Imidazo[1,2b]pyridazine Compounds As Trk Kinase Inhibitors | ARRAY BIOPHARMA INC | 2014-08-06 | — | — | CN | disclosed |
| CN-102224153-B | Substituted imidazo [1,2-B ] pyridazine compounds as TRK kinase inhibitors | ARRAY BIOPHARMA INC | 2014-04-30 | — | — | CN | disclosed |
| CN-102224153-A | Substituted imidazo [1,2-B ] pyridazine compounds as TRK kinase inhibitors | ARRAY BIOPHARMA INC | 2011-10-19 | — | — | CN | disclosed |
| EP-1506197-A1 | ACYL BICYCLIC DERIVATIVES OF PYRROL | GLAXO GROUP LIMITED (GB) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097646-A1 | ACYL BICYCLIX DERIVATIVES OF PYRROL | GLAXO GROUP LIMITED (GB) | 2003-11-27 | — | — | WO | disclosed |
| US-4971958-A | CALCIUM METABOLISM | BOEHRINGER MANNHEIM GMBH (DE) | 1990-11-20 | — | — | US | disclosed |
| EP-0273190-A1 | Diphosphoric acid derivatives, process for their preparation and pharmaceuticals containing them | Roche Diagnostics GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |