Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 19/20 | 0.73 |
| ▸ | MMP13 | P45452 | 15/20 | 0.72 |
| ▸ | MMP1 | P03956 | 13/20 | 0.72 |
| ▸ | MMP9 | P14780 | 13/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroxyamine SCHEMBL4033698 | 0.91 | ADAM17 (0.61) | ADAM17MMP13MMP1MMP9 | |
| SCHEMBL4033702 | 0.91 | ADAM17 (0.60) | ADAM17MMP13MMP1MMP9 | |
| SCHEMBL6270058 | 0.88 | ADAM17 (0.57) | ADAM17MMP13MMP1MMP9 | |
| SCHEMBL4027101 | 0.85 | ADAM17 (1.00) | ADAM17MMP13MMP1MMP9 | |
| SCHEMBL6265558 | 0.84 | ADAM17 (1.00) | ADAM17MMP13MMP1MMP9 | |
| SCHEMBL6269908 | 0.83 | ADAM17 (0.84) | ADAM17MMP13MMP1MMP9 | |
| SCHEMBL4026389 | 0.82 | ADAM17 (1.00) | ADAM17MMP13MMP1MMP9 | |
| SCHEMBL6262973 | 0.81 | ADAM17 (1.00) | ADAM17MMP13MMP1MMP9 | |
| SCHEMBL6262885 | 0.81 | ADAM17 (1.00) | ADAM17MMP13MMP1MMP9 | |
| SCHEMBL7423131 | 0.81 | ADAM17 (0.53) | ADAM17MMP13MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147085-B1 | ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS / TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS | WYETH CORP (US) | 2005-11-16 | — | — | EP | claimed |
| EP-1147085-B1 | ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS / TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS | WYETH CORP (US) | 2005-11-16 | — | — | EP | disclosed |