Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 6/20 | 0.49 |
| ▸ | SYK | P43405 | 10/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6280533 | 0.90 | MAPK8 (0.50) | MAPK8SYKAURKA | |
| SCHEMBL6262205 | 0.88 | MAPK8 (0.47) | MAPK8SYK | |
| SCHEMBL6265223 | 0.88 | PIK3CA (0.53) | MAPK8SYKAURKAPIK3R1PIK3CA | |
| SCHEMBL6264959 | 0.87 | MAPK8 (0.46) | MAPK8SYKAURKA | |
| SCHEMBL6261165 | 0.87 | MAPK8 (0.46) | MAPK8SYK | |
| SCHEMBL6264925 | 0.87 | MAPK8 (0.57) | MAPK8SYKADORA3 | |
| SCHEMBL6264246 | 0.84 | AURKA (0.60) | MAPK8SYKAURKAADORA3 | |
| SCHEMBL6261835 | 0.83 | FYN (0.48) | MAPK8SYKFYNAURKA | |
| SCHEMBL6270503 | 0.83 | AURKA (0.57) | MAPK8SYKAURKA | |
| SCHEMBL6264936 | 0.81 | MAPK8 (0.58) | MAPK8SYKAURKAADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005085252-A1 | IMIDAZO ‘1,2-A’ PYRAZINE COMPOUNDS WHICH INTERACT WITH PROTEIN KINASES | BIOFOCUS DISCOVERY LIMITED (GB) | 2005-09-15 | — | — | WO | claimed |