Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.49 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.47 |
| ▸ | MERTK | Q12866 | 2/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 3/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6280533 | 0.87 | MAPK8 (0.50) | AURKAMAPK8TYRO3MERTKEPHB4 | |
| SCHEMBL6265223 | 0.85 | PIK3CA (0.53) | AURKAMAPK8EPHB4SYK | |
| SCHEMBL6264936 | 0.85 | MAPK8 (0.58) | AURKAMAPK8TYRO3MERTKEPHB4 | |
| SCHEMBL6270503 | 0.84 | AURKA (0.57) | AURKAMAPK8SYK | |
| SCHEMBL6260383 | 0.84 | SYK (0.59) | AURKAMAPK8SYKADORA3TMIGD3 | |
| SCHEMBL6263352 | 0.84 | MAPK8 (0.49) | AURKAMAPK8SYKADORA3 | |
| SCHEMBL6262086 | 0.82 | SYK (0.60) | MAPK8SYK | |
| SCHEMBL6264925 | 0.82 | MAPK8 (0.57) | MAPK8EPHB4SYKADORA3TMIGD3 | |
| SCHEMBL6264254 | 0.82 | FYN (0.48) | AURKAMAPK8EPHB4SYK | |
| SCHEMBL6263073 | 0.81 | RXFP1 (0.55) | AURKAEPHB4SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005085252-A1 | IMIDAZO ‘1,2-A’ PYRAZINE COMPOUNDS WHICH INTERACT WITH PROTEIN KINASES | BIOFOCUS DISCOVERY LIMITED (GB) | 2005-09-15 | — | — | WO | claimed |