Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA known ✓ | P35790 | 9/20 | 0.71 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6263179 | 0.98 | CHKA (0.68) | CHKATSHRALDH1A1SMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL21061013 | 0.96 | CHKA (0.66) | CHKATSHRALDH1A1SMN1; SMN2LMNA | |
| Bromide SCHEMBL5206067 | 0.83 | ALDH1A1 (0.62) | CHKAALDH1A1SMN1; SMN2LMNAHTT | |
| Bromide SCHEMBL8890844 | 0.83 | CHKA (0.64) | CHKAALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL26522365 | 0.82 | TDP1 (0.64) | CHKAALDH1A1SMN1; SMN2LMNAHTT | |
| Bromide SCHEMBL8971005 | 0.82 | CHKA (0.58) | CHKATSHRALDH1A1SMN1; SMN2LMNA | |
| Bromide SCHEMBL17967626 | 0.81 | CHKA (0.58) | CHKAALDH1A1SMN1; SMN2LMNAHTT | |
| Bromide SCHEMBL11693463 | 0.81 | CHKA (0.63) | CHKAALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL10326023 | 0.80 | CHKA (0.61) | CHKAALDH1A1SMN1; SMN2LMNAHTT | |
| Benzyl Viologen SCHEMBL4079047 | 0.80 | ALDH1A1 (0.71) | CHKAALDH1A1SMN1; SMN2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250195484-A1 | CEREBLON LIGANDS AND USES THEREOF | UNIV MICHIGAN (US) | 2025-06-19 | — | — | US | disclosed |
| EP-4554948-A1 | TETRAHYDRONAPHTHALENE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | Regents of the University of Michigan (US) | 2025-05-21 | — | — | EP | disclosed |
| WO-2024015409-A1 | CHROMAN DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-01-18 | — | — | WO | disclosed |
| WO-2024015408-A1 | INDAZOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | REGENTS OF THE UNIVESITY OF MICHIGAN (US) | 2024-01-18 | — | — | WO | disclosed |
| WO-2023201012-A1 | IKZF2 DEGRADERS AND USES THEREOF | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2023-10-19 | — | — | WO | disclosed |
| WO-2023183607-A1 | CEREBLON LIGANDS AND USES THEREOF | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2023-09-28 | — | — | WO | disclosed |
| WO-2005076749-A2 | A NOVEL PROCESS FOR THE PREPARATION OF 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE | JUBILANT ORGANOSYS LIMITED (IN) | 2005-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250195484-A1 | CEREBLON LIGANDS AND USES THEREOF | CRBN, CDR2, CHLSN | CHKA 545/4885ACHE 1251/4885TSHR 2521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.