Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7615401 | 0.87 | KDM4E (0.53) | HSD17B10ALDH1A1TRPV1KDM4EALOX5 | |
| SCHEMBL7615406 | 0.87 | KDM4E (0.53) | HSD17B10ALDH1A1TRPV1KDM4EALOX5 | |
| SCHEMBL2728405 | 0.83 | KDM4E (0.53) | HSD17B10ALDH1A1TRPV1KDM4EALOX5 | |
| SCHEMBL2728401 | 0.83 | KDM4E (0.53) | HSD17B10ALDH1A1TRPV1KDM4EALOX5 | |
| Hydrochloric Acid SCHEMBL27910221 | 0.82 | KDM4E (0.51) | HSD17B10ALDH1A1TRPV1KDM4EALOX5 | |
| SCHEMBL30263749 | 0.80 | KDM4E (0.56) | HSD17B10ALDH1A1KDM4EALOX5MEN1 | |
| SCHEMBL30207038 | 0.80 | KDM4E (0.56) | HSD17B10ALDH1A1KDM4EALOX5MEN1 | |
| SCHEMBL13797243 | 0.80 | KDM4E (0.56) | HSD17B10ALDH1A1KDM4EALOX5MEN1 | |
| SCHEMBL20681307 | 0.80 | KDM4E (0.56) | HSD17B10ALDH1A1KDM4EALOX5MEN1 | |
| SCHEMBL30567327 | 0.80 | KDM4E (0.56) | HSD17B10ALDH1A1KDM4EALOX5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1587779-A1 | 5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL 2,6-DIFLUOROHEPTATRIENOIC ACID DERIVATIVES HAVING SERUM GLUCOSE REDUCING ACTIVITY | Allergan, Inc. (US) | 2005-10-26 | — | — | EP | disclosed |
| WO-2004065345-A1 | 5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL 2,6-DIFLUOROHEPTATRIENOIC ACID DERIVATIVES HAVING SERUM GLUCOSE REDUCING ACTIVITY | ALLERGAN, INC. (US) | 2004-08-05 | — | — | WO | disclosed |
| US-6759547-B1 | REDUCES SERUM GLUCOSE AND SERUM TRIGLYCERIDE LEVELS IN DIABETIC MAMMALS WITHOUT THE UNDESIRABLE PROPERTIES OF REDUCING SERUM THYROXINE LEVELS AND TRANSIENTLY RAISING TRIGLYCERIDE LEVELS | ALLERGAN, INC. | 2004-07-06 | — | — | US | disclosed |