Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | DAO | P14920 | 3/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | NQO2 | P16083 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26666411 | 0.80 | DAO (0.47) | RXFP1BRD4DAOPDE2APDE3B | |
| SCHEMBL31473379 | 0.77 | RXFP1 (0.49) | RXFP1BRD4DAOPDE2APDE3B | |
| SCHEMBL27298137 | 0.77 | RXFP1 (0.49) | RXFP1BRD4DAOPDE2APDE3B | |
| SCHEMBL194512 | 0.77 | DAO (0.69) | RXFP1BRD4DAOLMNAKDM4E | |
| SCHEMBL14992295 | 0.74 | DAO (0.41) | BRD4DAOPDE2APDE3BPDE3A | |
| SCHEMBL27298139 | 0.73 | TNKS (0.43) | RXFP1BRD4DAOLMNAKDM4E | |
| SCHEMBL31473421 | 0.73 | TNKS (0.43) | RXFP1BRD4DAOLMNAKDM4E | |
| SCHEMBL31473360 | 0.73 | RXFP1 (0.42) | RXFP1BRD4DAOLMNAKDM4E | |
| SCHEMBL31539797 | 0.71 | PDE2A (0.39) | RXFP1BRD4PDE2APDE3BPDE3A | |
| SCHEMBL16739031 | 0.71 | BRD4 (0.51) | RXFP1BRD4DAOPDE2APDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603079-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | Merck Sharp & Dohme Corp. (US) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |