Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | F10 | P00742 | 14/20 | 0.50 |
| ▸ | RAD52 | P43351 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 2/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5698752 | 0.91 | MAPT (0.59) | PTGS1PTGS2MAPTALDH1A1POLB | |
| SCHEMBL6353347 | 0.85 | PTGS2 (0.72) | PTGS1PTGS2F10 | |
| SCHEMBL8735027 | 0.76 | PTGS2 (0.59) | PTGS1PTGS2F10F2 | |
| SCHEMBL6793988 | 0.75 | CCNA2 (0.62) | F10RAD52F2CCNA2CDK2 | |
| SCHEMBL11868715 | 0.75 | RAD52 (0.68) | MAPTALDH1A1RAD52KDM4EMEN1 | |
| SCHEMBL11867763 | 0.74 | RAD52 (0.70) | PTGS1PTGS2MAPTALDH1A1RAD52 | |
| SCHEMBL7230422 | 0.74 | PTGS1 (0.47) | PTGS1PTGS2 | |
| SCHEMBL6339161 | 0.73 | PTGS2 (0.74) | PTGS1PTGS2 | |
| SCHEMBL6487680 | 0.73 | CCNA2 (0.55) | PTGS1PTGS2RAD52KDM4EMEN1 | |
| SCHEMBL6352140 | 0.73 | RAD52 (0.56) | PTGS1PTGS2ALDH1A1RAD52SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005044194-A2 | TREATMENT OR PREVENTION OF NEOPLASIA BY USE OF AN Hsp90 INHIBITOR | PHARMACIA CORPORATION (US) | 2005-05-19 | — | — | WO | disclosed |