Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 18/20 | 0.51 |
| ▸ | MMP2 | P08253 | 18/20 | 0.51 |
| ▸ | ADAM17 | P78536 | 19/20 | 0.50 |
| ▸ | MMP14 | P50281 | 9/20 | 0.49 |
| ▸ | MMP1 | P03956 | 5/20 | 0.49 |
| ▸ | MMP9 | P14780 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6265331 | 0.89 | ADAM17 (0.56) | MMP13MMP2ADAM17MMP14MMP1 | |
| SCHEMBL6264852 | 0.86 | ADAM17 (0.55) | MMP13MMP2ADAM17MMP14MMP1 | |
| SCHEMBL6263133 | 0.81 | ADAM17 (0.49) | MMP13MMP2ADAM17MMP14MMP1 | |
| SCHEMBL7377838 | 0.76 | ADAM17 (0.62) | MMP13MMP2ADAM17MMP14MMP1 | |
| SCHEMBL6264917 | 0.68 | ADAM17 (0.81) | MMP13MMP2ADAM17MMP14MMP1 | |
| SCHEMBL6268705 | 0.67 | ADAM17 (0.69) | MMP13MMP2ADAM17MMP14MMP1 | |
| SCHEMBL6261852 | 0.67 | ADAM17 (0.68) | MMP13MMP2ADAM17MMP14MMP1 | |
| SCHEMBL6261855 | 0.67 | ADAM17 (0.68) | MMP13MMP2ADAM17MMP14MMP1 | |
| SCHEMBL6269025 | 0.67 | ADAM17 (0.70) | MMP13MMP2ADAM17MMP14MMP1 | |
| SCHEMBL6269022 | 0.67 | ADAM17 (0.82) | MMP13MMP2ADAM17MMP14MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147085-B1 | ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS / TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS | WYETH CORP (US) | 2005-11-16 | — | — | EP | claimed |
| EP-1147085-B1 | ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS / TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS | WYETH CORP (US) | 2005-11-16 | — | — | EP | disclosed |